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PubMed COVID-19 Clinical Care

981 - 990 of 4290 results found

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Date
Wednesday, November 22, 2023 - 4:00 AM
Description
Since 2019, SARS-CoV-2 has evolved rapidly and gained resistance to multiple therapeutics targeting the virus. Development of host-directed antivirals offers broad-spectrum intervention against different variants of concern. Host proteases, TMPRSS2

SARS-CoV-2 and innate immunity: the good, the bad, and the "goldilocks"

Date
Tuesday, November 21, 2023 - 4:00 AM
Description
An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of immunity. Knowledge about this interplay can not only help us identify biological mechanisms but also reveal pathogen vulnerabilities that can be leveraged